Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_ac1 Exclusive	genAge	3.33e-04	2.07e-04	9.14e-13	2.24e-39
genAge Exclusive	wellderly_ac1	8.83e-02	6.39e-01	2.04e-15	1.75e-04
wellderly_ac1 Exclusive	genAge Exclusive	9.48e-05	1.24e-03	9.05e-13	3.26e-38
genAge Exclusive	wellderly_ac1 Exclusive	3.20e-01	6.77e-01	1.26e-14	1.15e-03
wellderly_ac1 Exclusive	Overlap	2.12e-01	2.24e-01	5.47e-02	3.07e-03
genAge Exclusive	Overlap	5.90e-09	2.71e-03	7.45e-12	3.44e-09
Overlap	Exclusives	9.71e-28	1.96e-26	5.22e-124	1.89e-79



Evaluating how well wellderly_ac1 genes are linked to genAge genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac1 Exclusive	genAge	0.75	-0.86	4.46	0.84	14.75
genAge Exclusive	wellderly_ac1	0.62	2.22	0.50	0.50	4.72
wellderly_ac1 Exclusive	genAge Exclusive	0.75	-1.15	4.62	0.88	15.77
genAge Exclusive	wellderly_ac1 Exclusive	0.60	2.01	0.21	0.32	4.78
wellderly_ac1 Exclusive	Overlap	0.89	0.34	1.66	0.91	3.29
genAge Exclusive	Overlap	1.00	3.35	2.11	2.42	3.49
Overlap	Exclusives	0.79	2.28	11.59	2.56	19.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac1 Exclusive	genAge	0.04	-1.70	6.95	0.06	23.57
genAge Exclusive	wellderly_ac1	0.02	13.14	13.10	6.22	24.01
wellderly_ac1 Exclusive	genAge Exclusive	0.04	-1.83	5.82	0.09	17.89
genAge Exclusive	wellderly_ac1 Exclusive	0.01	1.48	0.85	0.53	5.74
wellderly_ac1 Exclusive	Overlap	0.00	-0.82	1.14	-0.34	8.72
genAge Exclusive	Overlap	0.30	29.81	48.26	89.95	482.80
Overlap	Exclusives	0.11	4.54	35.81	11.04	84.14

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_ac1 Exclusive	132	132	
genAge Exclusive	302	301	TERC
Overlap	5	5