Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly Exclusive	aging	8.15e-01	5.51e-01	6.35e-01	8.26e-29
aging Exclusive	wellderly	1.06e-01	6.77e-01	3.81e-04	6.45e-01
wellderly Exclusive	aging Exclusive	8.55e-01	6.51e-01	5.39e-01	1.59e-28
aging Exclusive	wellderly Exclusive	8.45e-02	7.66e-01	6.28e-04	6.44e-01
wellderly Exclusive	Overlap	1.19e-01	1.98e-02	2.97e-01	1.19e-01
aging Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	7.02e-02	1.67e-20	1.76e-143	7.69e-71



Evaluating how well wellderly genes are linked to aging genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly Exclusive	aging	0.71	0.22	-0.91	-0.19	13.60
aging Exclusive	wellderly	0.49	1.09	-0.94	-0.51	-0.46
wellderly Exclusive	aging Exclusive	0.71	0.14	-0.69	-0.22	13.50
aging Exclusive	wellderly Exclusive	0.49	0.58	-0.56	-0.84	-0.56
wellderly Exclusive	Overlap	0.97	1.17	64126503034843.50	0.98	1.77
aging Exclusive	Overlap	1.00	1.78	-9462337698014.00	0.86	1.80
Overlap	Exclusives	0.76	42551699932630.00	10.76	1.82	18.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly Exclusive	aging	0.03	-0.19	0.15	-0.56	16.13
aging Exclusive	wellderly	0.01	1.70	0.21	-0.11	0.07
wellderly Exclusive	aging Exclusive	0.03	-0.29	0.28	-0.63	17.15
aging Exclusive	wellderly Exclusive	0.01	0.71	0.26	-0.27	-0.24
wellderly Exclusive	Overlap	0.00	1.67	1171650813227046.50	0.79	1.47
aging Exclusive	Overlap	0.01	7.16	-1200959900632131.00	3.36	15.01
Overlap	Exclusives	0.06	inf	18.30	1.67	28.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly Exclusive	102	100	ZNF883;CBWD6
aging Exclusive	306	305	TERC
Overlap	1	1