Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_ac1	KW_Aging_Genes	2.55e-02	3.95e-01	8.18e-01	7.43e-01
KW_Aging_Genes	wellderly_ac1	6.60e-01	3.35e-01	7.66e-01	9.97e-03



Evaluating how well wellderly_ac1 genes are linked to KW_Aging_Genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac1	KW_Aging_Genes	0.53	-2.00	-1.64	-0.91	0.76
KW_Aging_Genes	wellderly_ac1	0.63	0.55	0.79	0.54	3.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac1	KW_Aging_Genes	0.00	-1.01	-1.14	-0.40	0.57
KW_Aging_Genes	wellderly_ac1	0.00	-0.19	-0.78	-0.24	1.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_ac1	54	54	
KW_Aging_Genes	80	77	LINC02049;KN3KRP;CDKN2B-AS1