Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_ac1	tier1_AD	6.94e-01	7.06e-01	5.32e-01	1.33e-01
tier1_AD	wellderly_ac1	9.89e-01	1.38e-01	2.10e-01	9.28e-04



Evaluating how well wellderly_ac1 genes are linked to tier1_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac1	tier1_AD	0.61	0.50	0.25	0.32	2.01
tier1_AD	wellderly_ac1	0.64	0.89	1.51	1.00	3.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac1	tier1_AD	0.00	-0.14	-0.20	-0.10	0.25
tier1_AD	wellderly_ac1	0.00	0.12	0.57	0.13	1.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_ac1	54	54	
tier1_AD	31	30	MS4A