Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_ac10 Exclusive	KW_Aging_Genes	4.56e-01	1.58e-02	2.03e-02	1.38e-05
KW_Aging_Genes Exclusive	wellderly_ac10	3.46e-01	4.50e-02	5.59e-03	1.83e-05
wellderly_ac10 Exclusive	KW_Aging_Genes Exclusive	6.34e-01	2.68e-02	2.68e-02	2.61e-05
KW_Aging_Genes Exclusive	wellderly_ac10 Exclusive	2.86e-01	5.20e-02	5.58e-03	1.24e-05
wellderly_ac10 Exclusive	Overlap	3.96e-02	2.77e-01	1.58e-01	2.18e-01
KW_Aging_Genes Exclusive	Overlap	5.74e-01	7.13e-01	5.35e-01	4.55e-01
Overlap	Exclusives	1.92e-04	1.45e-02	4.32e-06	3.84e-08



Evaluating how well wellderly_ac10 genes are linked to KW_Aging_Genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac10 Exclusive	KW_Aging_Genes	0.65	1.68	3.66	2.02	5.00
KW_Aging_Genes Exclusive	wellderly_ac10	0.62	1.00	2.50	1.41	4.70
wellderly_ac10 Exclusive	KW_Aging_Genes Exclusive	0.65	1.46	2.96	2.45	4.48
KW_Aging_Genes Exclusive	wellderly_ac10 Exclusive	0.62	1.07	2.75	1.11	5.15
wellderly_ac10 Exclusive	Overlap	0.87	3.00	1.20	1.36	1.42
KW_Aging_Genes Exclusive	Overlap	0.67	1.07	0.56	0.87	0.73
Overlap	Exclusives	0.63	1.05	4.12	1.01	7.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac10 Exclusive	KW_Aging_Genes	0.01	0.21	1.72	0.50	3.29
KW_Aging_Genes Exclusive	wellderly_ac10	0.01	0.63	2.04	1.46	2.69
wellderly_ac10 Exclusive	KW_Aging_Genes Exclusive	0.01	0.13	1.51	1.12	3.75
KW_Aging_Genes Exclusive	wellderly_ac10 Exclusive	0.01	0.72	1.85	0.94	4.22
wellderly_ac10 Exclusive	Overlap	0.00	3.45	-0.14	0.34	-0.03
KW_Aging_Genes Exclusive	Overlap	0.00	0.02	-0.25	0.01	-0.21
Overlap	Exclusives	0.02	0.52	3.14	0.78	6.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_ac10 Exclusive	138	138	
KW_Aging_Genes Exclusive	79	76	KN3KRP;LINC02049;CDKN2B-AS1
Overlap	1	1