Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_ac10	tier1_AD	8.66e-02	9.23e-01	2.61e-01	2.91e-01
tier1_AD	wellderly_ac10	1.76e-01	5.98e-01	1.23e-01	5.39e-04



Evaluating how well wellderly_ac10 genes are linked to tier1_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac10	tier1_AD	0.60	-0.49	0.21	0.07	2.16
tier1_AD	wellderly_ac10	0.60	0.93	1.01	0.50	4.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac10	tier1_AD	0.00	-0.61	0.06	-0.12	-0.01
tier1_AD	wellderly_ac10	0.01	0.52	0.12	0.37	1.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_ac10	139	139	
tier1_AD	31	30	MS4A