Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) wellderly_ac10 Exclusive genAge 1.09e-01 5.47e-09 5.27e-11 6.79e-52 genAge Exclusive wellderly_ac10 2.07e-01 3.36e-01 3.64e-15 1.70e-07 wellderly_ac10 Exclusive genAge Exclusive 6.07e-02 1.65e-08 4.65e-12 1.21e-51 genAge Exclusive wellderly_ac10 Exclusive 2.59e-01 4.22e-01 1.58e-15 4.57e-07 wellderly_ac10 Exclusive Overlap 6.83e-02 1.94e-03 1.42e-02 4.97e-04 genAge Exclusive Overlap 7.71e-02 1.46e-06 4.36e-07 1.98e-04 Overlap Exclusives 7.27e-120 3.89e-42 8.67e-215 1.80e-111 Evaluating how well wellderly_ac10 genes are linked to genAge genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) wellderly_ac10 Exclusive genAge 0.77 0.67 5.49 1.38 17.44 genAge Exclusive wellderly_ac10 0.62 3.60 2.00 1.26 5.20 wellderly_ac10 Exclusive genAge Exclusive 0.76 0.45 5.66 1.54 17.37 genAge Exclusive wellderly_ac10 Exclusive 0.61 3.32 1.38 1.35 4.52 wellderly_ac10 Exclusive Overlap 0.96 1.24 1.81 1.53 2.67 genAge Exclusive Overlap 0.99 3.09 1.64 1.66 2.64 Overlap Exclusives 0.84 5.16 18.16 3.46 23.92 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) wellderly_ac10 Exclusive genAge 0.04 -1.26 5.79 -0.20 23.09 genAge Exclusive wellderly_ac10 0.02 2.37 19.16 7.61 15.79 wellderly_ac10 Exclusive genAge Exclusive 0.04 -1.47 5.83 -0.09 23.56 genAge Exclusive wellderly_ac10 Exclusive 0.01 1.64 0.05 0.92 3.20 wellderly_ac10 Exclusive Overlap 0.00 -0.59 -0.10 -0.30 4.20 genAge Exclusive Overlap 0.44 2.51 2515.31 12.39 671.60 Overlap Exclusives 0.10 9.31 39.91 6.95 67.15 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes wellderly_ac10 Exclusive 136 136 genAge Exclusive 304 303 TERC Overlap 3 3