Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
102 wellderly Exclusive	Kevin GS	7.85e-01	4.98e-01	6.17e-01	1.93e-01
Kevin GS Exclusive	102 wellderly	6.88e-01	3.64e-01	2.55e-01	6.34e-01
102 wellderly Exclusive	Kevin GS Exclusive	8.27e-01	5.88e-01	4.95e-01	2.89e-01
Kevin GS Exclusive	102 wellderly Exclusive	5.97e-01	3.00e-01	2.97e-01	6.01e-01
102 wellderly Exclusive	Overlap	9.90e-02	1.98e-02	4.55e-01	3.96e-02
Kevin GS Exclusive	Overlap	2.77e-01	1.98e-02	5.94e-02	5.94e-02
Overlap	Exclusives	4.62e-04	7.05e-01	1.57e-45	2.65e-01



Evaluating how well 102 wellderly genes are linked to Kevin GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
102 wellderly Exclusive	Kevin GS	0.56	0.51	-0.21	0.11	2.08
Kevin GS Exclusive	102 wellderly	0.53	1.40	1.45	1.57	0.90
102 wellderly Exclusive	Kevin GS Exclusive	0.56	0.33	-0.13	-0.08	1.77
Kevin GS Exclusive	102 wellderly Exclusive	0.53	1.80	1.65	1.53	0.96
102 wellderly Exclusive	Overlap	0.97	1.10	50081600512225.00	0.80	1.67
Kevin GS Exclusive	Overlap	0.97	0.59	881225442216575.00	0.90	1.79
Overlap	Exclusives	0.55	201373092329491.00	1.37	0.75	2.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
102 wellderly Exclusive	Kevin GS	0.01	0.17	0.08	0.02	1.15
Kevin GS Exclusive	102 wellderly	0.01	0.63	0.02	0.30	0.17
102 wellderly Exclusive	Kevin GS Exclusive	0.00	-0.03	0.16	-0.10	0.30
Kevin GS Exclusive	102 wellderly Exclusive	0.01	0.20	1.08	0.72	0.43
102 wellderly Exclusive	Overlap	0.00	1.05	893038852400733.00	0.15	0.54
Kevin GS Exclusive	Overlap	0.00	-0.13	20740945745735456.00	0.55	1.95
Overlap	Exclusives	0.01	958829736645282.00	2.01	0.35	2.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
102 wellderly Exclusive	101	99	ZNF883;CBWD6
Kevin GS Exclusive	79	76	KN3KRP;CDKN2B-AS1;LINC02049
Overlap	1	1