Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
177 wellderly Exclusive	Aging	3.21e-01	2.07e-02	1.12e-03	1.00e-26
Aging Exclusive	177 wellderly	4.06e-03	3.60e-01	3.28e-07	3.31e-01
177 wellderly Exclusive	Aging Exclusive	1.30e-01	1.08e-02	4.63e-04	1.72e-26
Aging Exclusive	177 wellderly Exclusive	2.63e-03	3.42e-01	1.47e-06	1.37e-01
177 wellderly Exclusive	Overlap	4.58e-01	3.50e-01	4.07e-01	6.18e-03
Aging Exclusive	Overlap	7.96e-02	6.49e-01	1.74e-06	1.21e-02
Overlap	Exclusives	3.28e-03	3.70e-14	1.05e-102	2.12e-69



Evaluating how well 177 wellderly genes are linked to Aging genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
177 wellderly Exclusive	Aging	0.70	-0.54	-3.40	-1.04	12.75
Aging Exclusive	177 wellderly	0.48	0.75	-1.02	-0.91	-0.74
177 wellderly Exclusive	Aging Exclusive	0.70	-0.75	-3.39	-1.44	11.02
Aging Exclusive	177 wellderly Exclusive	0.48	0.63	-1.20	-0.80	-1.00
177 wellderly Exclusive	Overlap	0.92	1.19	2.33	1.40	2.62
Aging Exclusive	Overlap	0.92	2.83	1.47	0.93	2.70
Overlap	Exclusives	0.72	2.31	8.30	2.25	16.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
177 wellderly Exclusive	Aging	0.03	-0.91	-2.49	-1.13	14.20
Aging Exclusive	177 wellderly	0.01	1.24	-0.51	-0.55	-0.60
177 wellderly Exclusive	Aging Exclusive	0.03	-1.06	-3.00	-1.39	13.58
Aging Exclusive	177 wellderly Exclusive	0.01	0.68	-0.56	-0.52	-0.97
177 wellderly Exclusive	Overlap	0.00	0.47	6.16	0.73	0.04
Aging Exclusive	Overlap	0.00	4.71	-1.69	2.76	5.22
Overlap	Exclusives	0.05	1.77	12.78	2.43	23.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
177 wellderly Exclusive	174	171	ZNF883;CBWD6;C14orf132
Aging Exclusive	304	303	TERC
Overlap	3	3