Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wellderly_AD_UKB_z3 Exclusive	tier1_31	4.38e-04	3.21e-05	2.13e-06	1.38e-06
tier1_31 Exclusive	Wellderly_AD_UKB_z3	2.96e-01	5.82e-01	1.82e-01	2.36e-02
Wellderly_AD_UKB_z3 Exclusive	tier1_31 Exclusive	3.16e-03	3.99e-04	2.67e-05	4.07e-05
tier1_31 Exclusive	Wellderly_AD_UKB_z3 Exclusive	5.95e-01	8.06e-01	4.72e-01	4.95e-02
Wellderly_AD_UKB_z3 Exclusive	Overlap	6.22e-02	1.59e-04	3.58e-02	5.00e-03
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	8.00e-06	6.89e-07	1.35e-15	8.72e-08



Evaluating how well Wellderly_AD_UKB_z3 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_AD_UKB_z3 Exclusive	tier1_31	0.77	2.28	4.87	2.96	5.06
tier1_31 Exclusive	Wellderly_AD_UKB_z3	0.56	0.92	0.63	0.74	2.13
Wellderly_AD_UKB_z3 Exclusive	tier1_31 Exclusive	0.75	2.09	3.97	2.87	4.76
tier1_31 Exclusive	Wellderly_AD_UKB_z3 Exclusive	0.54	0.56	-0.02	0.41	1.46
Wellderly_AD_UKB_z3 Exclusive	Overlap	0.96	1.77	2.82	2.12	2.68
tier1_31 Exclusive	Overlap	1.00	2.67	3.07	2.66	3.18
Overlap	Exclusives	0.65	5.03	4.47	3.03	5.52

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_AD_UKB_z3 Exclusive	tier1_31	0.01	10.06	23.97	11.10	2.21
tier1_31 Exclusive	Wellderly_AD_UKB_z3	0.02	7.51	13.81	17.42	21.26
Wellderly_AD_UKB_z3 Exclusive	tier1_31 Exclusive	0.01	5.88	12.06	6.75	5.60
tier1_31 Exclusive	Wellderly_AD_UKB_z3 Exclusive	0.01	4.19	3.63	4.60	4.28
Wellderly_AD_UKB_z3 Exclusive	Overlap	0.01	2.83	27.99	11.42	10.92
tier1_31 Exclusive	Overlap	0.10	231.23	102.92	322.86	328.73
Overlap	Exclusives	0.08	76.10	104.47	75.99	114.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wellderly_AD_UKB_z3 Exclusive	87	87	
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3