Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wellderly_UKB_z3	tier1_31	2.46e-01	7.60e-02	4.52e-04	1.22e-04
tier1_31	Wellderly_UKB_z3	3.85e-01	6.20e-01	7.35e-01	2.64e-01



Evaluating how well Wellderly_UKB_z3 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_UKB_z3	tier1_31	0.71	1.03	2.59	1.64	4.37
tier1_31	Wellderly_UKB_z3	0.53	-0.83	-1.26	-0.54	0.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_UKB_z3	tier1_31	0.00	0.82	1.40	0.77	3.34
tier1_31	Wellderly_UKB_z3	0.00	0.05	0.22	0.47	1.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wellderly_UKB_z3	49	49	
tier1_31	31	30	MS4A