Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wellderly_AD_UKB_z3 Exclusive	agegene_human	7.14e-01	1.67e-01	3.28e-02	6.60e-29
agegene_human Exclusive	Wellderly_AD_UKB_z3	4.36e-02	6.90e-01	3.78e-06	7.97e-02
Wellderly_AD_UKB_z3 Exclusive	agegene_human Exclusive	4.67e-01	1.69e-01	2.01e-01	2.22e-28
agegene_human Exclusive	Wellderly_AD_UKB_z3 Exclusive	2.57e-02	6.44e-01	1.41e-05	1.26e-01
Wellderly_AD_UKB_z3 Exclusive	Overlap	7.89e-01	7.89e-01	7.89e-01	2.54e-01
agegene_human Exclusive	Overlap	4.36e-07	7.71e-02	4.36e-07	1.74e-06
Overlap	Exclusives	2.70e-12	1.58e-31	6.48e-118	4.55e-77



Evaluating how well Wellderly_AD_UKB_z3 genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_AD_UKB_z3 Exclusive	agegene_human	0.70	0.04	-2.62	0.03	12.47
agegene_human Exclusive	Wellderly_AD_UKB_z3	0.55	0.72	0.06	0.31	1.88
Wellderly_AD_UKB_z3 Exclusive	agegene_human Exclusive	0.70	-0.28	-2.63	-0.19	11.32
agegene_human Exclusive	Wellderly_AD_UKB_z3 Exclusive	0.54	0.44	0.04	-0.06	1.13
Wellderly_AD_UKB_z3 Exclusive	Overlap	0.76	-0.38	-0.64	-0.41	1.69
agegene_human Exclusive	Overlap	1.00	2.96	1.28	2.40	3.19
Overlap	Exclusives	0.80	4.28	11.82	3.10	20.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_AD_UKB_z3 Exclusive	agegene_human	0.03	-0.41	-1.65	-0.16	12.86
agegene_human Exclusive	Wellderly_AD_UKB_z3	0.02	42.79	17.57	20.31	23.09
Wellderly_AD_UKB_z3 Exclusive	agegene_human Exclusive	0.03	-0.71	-1.82	-0.34	11.79
agegene_human Exclusive	Wellderly_AD_UKB_z3 Exclusive	0.00	-0.47	-0.49	-0.49	0.14
Wellderly_AD_UKB_z3 Exclusive	Overlap	0.00	1.47	7.29	3.43	6.09
agegene_human Exclusive	Overlap	0.37	96.19	590.16	238.68	663.60
Overlap	Exclusives	0.10	7.76	42.67	10.61	89.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wellderly_AD_UKB_z3 Exclusive	87	87	
agegene_human Exclusive	304	302	TOP 1.00;TERC
Overlap	3	3