Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wellderly_UKB_z3 Exclusive	agegene_human	1.75e-02	1.43e-03	4.84e-05	2.48e-31
agegene_human Exclusive	Wellderly_UKB_z3	2.77e-02	7.04e-01	7.46e-04	3.06e-01
Wellderly_UKB_z3 Exclusive	agegene_human Exclusive	1.92e-02	1.42e-03	4.97e-04	1.20e-30
agegene_human Exclusive	Wellderly_UKB_z3 Exclusive	2.07e-02	7.45e-01	2.30e-03	3.32e-01
Wellderly_UKB_z3 Exclusive	Overlap	3.95e-01	2.11e-01	4.68e-01	9.00e-01
agegene_human Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	5.03e-24	9.47e-25	1.31e-124	5.74e-96



Evaluating how well Wellderly_UKB_z3 genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_UKB_z3 Exclusive	agegene_human	0.71	0.04	-2.46	0.46	12.46
agegene_human Exclusive	Wellderly_UKB_z3	0.56	-3.17	-0.73	0.09	1.49
Wellderly_UKB_z3 Exclusive	agegene_human Exclusive	0.71	0.07	-2.84	0.42	13.69
agegene_human Exclusive	Wellderly_UKB_z3 Exclusive	0.55	-2.98	-0.57	-0.28	1.48
Wellderly_UKB_z3 Exclusive	Overlap	0.57	-1.87	-1.84	-1.81	0.28
agegene_human Exclusive	Overlap	1.00	3.08	1.36	2.18	2.67
Overlap	Exclusives	0.83	3.96	13.31	2.43	21.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_UKB_z3 Exclusive	agegene_human	0.03	-0.56	-2.53	0.27	10.18
agegene_human Exclusive	Wellderly_UKB_z3	0.03	66.75	32.21	54.50	40.02
Wellderly_UKB_z3 Exclusive	agegene_human Exclusive	0.03	-0.48	-2.86	0.11	11.50
agegene_human Exclusive	Wellderly_UKB_z3 Exclusive	0.00	-2.73	-0.78	-0.15	0.52
Wellderly_UKB_z3 Exclusive	Overlap	0.00	-0.85	-0.45	-0.99	-0.21
agegene_human Exclusive	Overlap	0.54	92.37	909.93	337.56	749.58
Overlap	Exclusives	0.11	7.32	45.93	7.12	82.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wellderly_UKB_z3 Exclusive	47	47	
agegene_human Exclusive	305	303	TERC;TOP 1.00
Overlap	2	2