Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wellderly_AD_UKB_z3 Exclusive	Kevin	1.26e-01	3.39e-02	3.97e-01	5.75e-01
Kevin Exclusive	Wellderly_AD_UKB_z3	1.86e-01	6.54e-01	7.20e-01	3.14e-01
Wellderly_AD_UKB_z3 Exclusive	Kevin Exclusive	1.08e-01	4.61e-02	5.35e-01	7.33e-01
Kevin Exclusive	Wellderly_AD_UKB_z3 Exclusive	1.71e-01	6.78e-01	6.01e-01	3.26e-01
Wellderly_AD_UKB_z3 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Kevin Exclusive	Overlap	2.57e-01	1.98e-02	3.96e-02	9.90e-02
Overlap	Exclusives	2.44e-02	7.21e-01	1.04e-41	7.10e-02



Evaluating how well Wellderly_AD_UKB_z3 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_AD_UKB_z3 Exclusive	Kevin	0.52	-0.77	-2.51	-0.81	0.57
Kevin Exclusive	Wellderly_AD_UKB_z3	0.55	0.16	0.82	0.61	1.77
Wellderly_AD_UKB_z3 Exclusive	Kevin Exclusive	0.52	-0.79	-2.00	-0.79	0.38
Kevin Exclusive	Wellderly_AD_UKB_z3 Exclusive	0.55	0.23	0.71	0.70	1.64
Wellderly_AD_UKB_z3 Exclusive	Overlap	1.00	1.44	593182126052330.00	1.17	1.85
Kevin Exclusive	Overlap	0.97	0.61	881225442216575.00	1.05	1.60
Overlap	Exclusives	0.56	61130212710529.00	0.23	0.54	2.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_AD_UKB_z3 Exclusive	Kevin	0.01	0.72	0.80	0.63	2.55
Kevin Exclusive	Wellderly_AD_UKB_z3	0.01	-0.47	0.31	0.10	0.68
Wellderly_AD_UKB_z3 Exclusive	Kevin Exclusive	0.00	0.11	-0.01	0.21	0.45
Kevin Exclusive	Wellderly_AD_UKB_z3 Exclusive	0.01	-0.43	-0.14	-0.03	0.29
Wellderly_AD_UKB_z3 Exclusive	Overlap	0.01	15.97	152067869958025888.00	5.61	10.95
Kevin Exclusive	Overlap	0.00	-0.09	20740945745735456.00	1.14	1.14
Overlap	Exclusives	0.02	inf	12.00	7.43	14.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wellderly_AD_UKB_z3 Exclusive	89	89	
Kevin Exclusive	79	76	KN3KRP;CDKN2B-AS1;LINC02049
Overlap	1	1