Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wellderly_UKB_z3	Kevin	5.07e-01	2.93e-01	7.05e-01	4.39e-01
Kevin	Wellderly_UKB_z3	3.26e-01	9.95e-01	8.01e-01	3.83e-01



Evaluating how well Wellderly_UKB_z3 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_UKB_z3	Kevin	0.53	-0.69	-2.02	-0.48	1.03
Kevin	Wellderly_UKB_z3	0.55	-0.70	-0.14	0.11	1.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_UKB_z3	Kevin	0.00	-0.52	-1.64	-0.30	0.31
Kevin	Wellderly_UKB_z3	0.00	-0.84	-0.52	-0.28	-0.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wellderly_UKB_z3	49	49	
Kevin	80	77	KN3KRP;LINC02049;CDKN2B-AS1