Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD_UKB_z3 Exclusive	Kevin	5.42e-01	3.37e-01	3.12e-01	8.59e-01
Kevin Exclusive	AD_UKB_z3	3.09e-01	4.33e-01	6.25e-01	3.70e-01
AD_UKB_z3 Exclusive	Kevin Exclusive	4.33e-01	3.25e-01	1.95e-01	8.87e-01
Kevin Exclusive	AD_UKB_z3 Exclusive	4.62e-01	4.76e-01	5.88e-01	3.21e-01
AD_UKB_z3 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Kevin Exclusive	Overlap	3.96e-01	1.98e-02	5.94e-02	1.19e-01
Overlap	Exclusives	6.44e-02	5.90e-01	4.62e-26	3.15e-02



Evaluating how well AD_UKB_z3 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD_UKB_z3 Exclusive	Kevin	0.53	-0.18	-0.98	-0.46	0.93
Kevin Exclusive	AD_UKB_z3	0.55	0.66	1.39	0.76	0.92
AD_UKB_z3 Exclusive	Kevin Exclusive	0.53	-0.24	-0.98	-0.64	0.83
Kevin Exclusive	AD_UKB_z3 Exclusive	0.54	0.95	1.30	0.85	0.86
AD_UKB_z3 Exclusive	Overlap	1.00	1.61	1556183469645194.00	1.55	1.75
Kevin Exclusive	Overlap	0.97	0.60	881225442216575.00	1.03	1.47
Overlap	Exclusives	0.57	12531470331529.00	1.41	0.90	2.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD_UKB_z3 Exclusive	Kevin	0.01	0.84	1.15	0.36	1.32
Kevin Exclusive	AD_UKB_z3	0.00	0.03	0.52	0.12	0.56
AD_UKB_z3 Exclusive	Kevin Exclusive	0.00	0.02	0.23	0.02	0.85
Kevin Exclusive	AD_UKB_z3 Exclusive	0.00	0.35	0.20	0.22	-0.05
AD_UKB_z3 Exclusive	Overlap	0.01	31.58	97562660150564816.00	17.53	17.84
Kevin Exclusive	Overlap	0.00	-0.23	20740945745735456.00	0.58	0.74
Overlap	Exclusives	0.02	4923896238493643.00	21.73	10.94	21.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD_UKB_z3 Exclusive	40	40	
Kevin Exclusive	79	76	KN3KRP;CDKN2B-AS1;LINC02049
Overlap	1	1