Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wellderly_Ad_UKB_z3_5 Exclusive	TIER1_GS	3.17e-03	3.52e-05	3.45e-07	1.76e-07
TIER1_GS Exclusive	Wellderly_Ad_UKB_z3_5	4.26e-01	6.00e-01	1.27e-01	6.28e-02
Wellderly_Ad_UKB_z3_5 Exclusive	TIER1_GS Exclusive	5.37e-03	2.32e-04	7.68e-06	3.37e-06
TIER1_GS Exclusive	Wellderly_Ad_UKB_z3_5 Exclusive	6.95e-01	3.91e-01	3.54e-01	1.57e-01
Wellderly_Ad_UKB_z3_5 Exclusive	Overlap	6.63e-02	5.79e-04	1.08e-02	1.59e-03
TIER1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.17e-08	1.50e-08	1.83e-13	3.67e-09



Evaluating how well Wellderly_Ad_UKB_z3_5 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_Ad_UKB_z3_5 Exclusive	TIER1_GS	0.78	1.58	5.04	2.78	5.73
TIER1_GS Exclusive	Wellderly_Ad_UKB_z3_5	0.61	1.44	1.04	1.71	2.65
Wellderly_Ad_UKB_z3_5 Exclusive	TIER1_GS Exclusive	0.76	1.72	4.36	2.51	4.78
TIER1_GS Exclusive	Wellderly_Ad_UKB_z3_5 Exclusive	0.58	0.62	0.47	1.18	1.63
Wellderly_Ad_UKB_z3_5 Exclusive	Overlap	0.96	1.55	2.93	2.15	3.12
TIER1_GS Exclusive	Overlap	1.00	2.76	2.56	2.67	3.08
Overlap	Exclusives	0.71	4.15	5.62	3.05	6.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_Ad_UKB_z3_5 Exclusive	TIER1_GS	0.01	3.76	15.72	7.11	17.91
TIER1_GS Exclusive	Wellderly_Ad_UKB_z3_5	0.02	25.28	13.18	33.42	26.99
Wellderly_Ad_UKB_z3_5 Exclusive	TIER1_GS Exclusive	0.01	3.18	8.26	4.43	4.21
TIER1_GS Exclusive	Wellderly_Ad_UKB_z3_5 Exclusive	0.00	4.34	2.66	2.90	2.20
Wellderly_Ad_UKB_z3_5 Exclusive	Overlap	0.00	4.50	19.08	9.60	15.81
TIER1_GS Exclusive	Overlap	0.10	280.50	100.51	244.73	219.55
Overlap	Exclusives	0.11	109.69	165.09	32.07	238.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wellderly_Ad_UKB_z3_5 Exclusive	42	42	
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3