Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wellderly_UKB_z3_5	TIER1_GS	7.65e-03	9.49e-02	2.79e-01	1.38e-01
TIER1_GS	Wellderly_UKB_z3_5	2.49e-01	2.12e-01	6.38e-01	2.58e-01



Evaluating how well Wellderly_UKB_z3_5 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_UKB_z3_5	TIER1_GS	0.58	-1.41	-0.74	-0.31	1.54
TIER1_GS	Wellderly_UKB_z3_5	0.55	-0.74	-1.27	-0.60	0.93

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_UKB_z3_5	TIER1_GS	0.00	-1.22	-1.03	-0.46	-0.06
TIER1_GS	Wellderly_UKB_z3_5	0.00	-0.89	-1.18	-0.51	-0.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wellderly_UKB_z3_5	24	24	
TIER1_GS	31	30	MS4A