Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD_UKB_z3_5 Exclusive	TIER1_GS	6.07e-09	4.53e-10	6.72e-09	6.49e-10
TIER1_GS Exclusive	AD_UKB_z3_5	5.95e-02	8.77e-02	6.09e-02	2.11e-02
AD_UKB_z3_5 Exclusive	TIER1_GS Exclusive	9.34e-07	2.19e-07	8.34e-07	3.81e-08
TIER1_GS Exclusive	AD_UKB_z3_5 Exclusive	6.75e-01	1.41e-01	8.27e-02	5.54e-02
AD_UKB_z3_5 Exclusive	Overlap	4.22e-04	1.52e-05	5.79e-04	3.56e-04
TIER1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	3.70e-13	2.09e-13	1.95e-16	1.66e-13



Evaluating how well AD_UKB_z3_5 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD_UKB_z3_5 Exclusive	TIER1_GS	0.86	3.96	6.71	4.76	6.38
TIER1_GS Exclusive	AD_UKB_z3_5	0.68	2.85	2.53	2.64	2.69
AD_UKB_z3_5 Exclusive	TIER1_GS Exclusive	0.84	3.14	6.81	3.45	6.29
TIER1_GS Exclusive	AD_UKB_z3_5 Exclusive	0.62	1.87	2.17	2.16	1.99
AD_UKB_z3_5 Exclusive	Overlap	0.98	2.45	3.83	2.48	2.96
TIER1_GS Exclusive	Overlap	1.00	2.71	2.51	2.66	2.88
Overlap	Exclusives	0.82	3.88	8.50	3.22	8.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD_UKB_z3_5 Exclusive	TIER1_GS	0.01	11.60	31.71	23.67	22.93
TIER1_GS Exclusive	AD_UKB_z3_5	0.03	58.98	35.10	90.28	4.52
AD_UKB_z3_5 Exclusive	TIER1_GS Exclusive	0.01	4.53	19.80	6.90	15.77
TIER1_GS Exclusive	AD_UKB_z3_5 Exclusive	0.01	12.09	10.47	12.70	11.45
AD_UKB_z3_5 Exclusive	Overlap	0.01	19.49	84.46	15.88	18.49
TIER1_GS Exclusive	Overlap	0.10	346.77	159.02	339.69	255.12
Overlap	Exclusives	0.17	92.69	435.06	51.17	391.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD_UKB_z3_5 Exclusive	18	18	
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3