Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wellderly_AD_UKB_z3_5 Exclusive	agegene_human	3.85e-03	1.70e-04	6.82e-01	4.74e-25
agegene_human Exclusive	Wellderly_AD_UKB_z3_5	6.03e-02	8.32e-01	3.67e-03	1.27e-01
Wellderly_AD_UKB_z3_5 Exclusive	agegene_human Exclusive	9.21e-03	2.47e-04	5.97e-01	1.10e-24
agegene_human Exclusive	Wellderly_AD_UKB_z3_5 Exclusive	4.01e-02	8.14e-01	6.97e-03	2.43e-01
Wellderly_AD_UKB_z3_5 Exclusive	Overlap	7.89e-01	7.89e-01	6.95e-01	4.94e-01
agegene_human Exclusive	Overlap	4.36e-07	7.71e-02	4.36e-07	1.74e-06
Overlap	Exclusives	3.62e-14	2.13e-34	9.25e-111	8.03e-88



Evaluating how well Wellderly_AD_UKB_z3_5 genes are linked to agegene_human genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_AD_UKB_z3_5 Exclusive	agegene_human	0.67	-0.65	-4.87	-0.84	10.22
agegene_human Exclusive	Wellderly_AD_UKB_z3_5	0.57	-0.59	-0.07	0.52	1.72
Wellderly_AD_UKB_z3_5 Exclusive	agegene_human Exclusive	0.67	-0.57	-4.45	-0.86	10.24
agegene_human Exclusive	Wellderly_AD_UKB_z3_5 Exclusive	0.54	-0.74	-0.41	0.04	0.95
Wellderly_AD_UKB_z3_5 Exclusive	Overlap	0.70	-0.47	-0.12	-0.57	1.27
agegene_human Exclusive	Overlap	1.00	2.81	1.41	2.89	3.02
Overlap	Exclusives	0.84	4.38	14.33	2.58	22.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_AD_UKB_z3_5 Exclusive	agegene_human	0.02	-0.78	-3.01	-0.56	7.11
agegene_human Exclusive	Wellderly_AD_UKB_z3_5	0.03	85.23	39.40	51.60	33.11
Wellderly_AD_UKB_z3_5 Exclusive	agegene_human Exclusive	0.02	-0.72	-3.15	-0.65	7.93
agegene_human Exclusive	Wellderly_AD_UKB_z3_5 Exclusive	0.00	-1.86	-0.92	-0.44	-0.21
Wellderly_AD_UKB_z3_5 Exclusive	Overlap	0.00	3.95	20.22	4.89	8.41
agegene_human Exclusive	Overlap	0.37	70.17	692.44	210.55	1053.82
Overlap	Exclusives	0.11	6.97	48.05	8.79	89.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wellderly_AD_UKB_z3_5 Exclusive	42	42	
agegene_human Exclusive	304	302	TERC;TOP 1.00
Overlap	3	3