Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) Wellderly_UKB_z3_5 Exclusive agegene_human 3.94e-06 2.10e-06 2.25e-03 1.78e-42 agegene_human Exclusive Wellderly_UKB_z3_5 5.23e-03 3.48e-01 8.94e-02 4.88e-01 Wellderly_UKB_z3_5 Exclusive agegene_human Exclusive 4.99e-05 3.71e-06 1.77e-02 1.03e-41 agegene_human Exclusive Wellderly_UKB_z3_5 Exclusive 2.51e-03 2.04e-01 2.14e-01 6.65e-01 Wellderly_UKB_z3_5 Exclusive Overlap 4.12e-01 2.05e-01 4.59e-01 5.74e-01 agegene_human Exclusive Overlap 9.85e-05 9.85e-05 9.85e-05 9.85e-05 Overlap Exclusives 4.50e-24 6.50e-27 8.95e-128 9.87e-108 Evaluating how well Wellderly_UKB_z3_5 genes are linked to agegene_human genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Wellderly_UKB_z3_5 Exclusive agegene_human 0.68 -0.98 -6.58 -0.77 11.32 agegene_human Exclusive Wellderly_UKB_z3_5 0.57 -3.93 -0.98 -0.40 1.15 Wellderly_UKB_z3_5 Exclusive agegene_human Exclusive 0.68 -0.67 -6.78 -1.02 10.64 agegene_human Exclusive Wellderly_UKB_z3_5 Exclusive 0.53 -4.27 -1.35 -0.73 0.47 Wellderly_UKB_z3_5 Exclusive Overlap 0.58 -2.36 -1.28 -1.85 0.48 agegene_human Exclusive Overlap 1.00 2.97 1.23 2.30 2.58 Overlap Exclusives 0.86 3.76 14.60 2.20 21.39 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Wellderly_UKB_z3_5 Exclusive agegene_human 0.02 -1.13 -5.18 -0.68 5.84 agegene_human Exclusive Wellderly_UKB_z3_5 0.05 80.49 80.97 127.76 81.90 Wellderly_UKB_z3_5 Exclusive agegene_human Exclusive 0.02 -0.83 -5.47 -0.85 6.18 agegene_human Exclusive Wellderly_UKB_z3_5 Exclusive 0.00 -3.70 -1.21 -0.98 -0.23 Wellderly_UKB_z3_5 Exclusive Overlap 0.00 -0.78 -0.85 -0.92 -0.30 agegene_human Exclusive Overlap 0.54 116.37 886.00 392.99 2302.78 Overlap Exclusives 0.11 6.53 47.53 7.02 103.78 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes Wellderly_UKB_z3_5 Exclusive 22 22 agegene_human Exclusive 305 303 TERC;TOPĀ 1.00 Overlap 2 2