Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) AD_UKB_z3_5 Exclusive agegene_human 5.00e-01 2.77e-01 1.52e-01 2.88e-43 agegene_human Exclusive AD_UKB_z3_5 6.25e-01 3.99e-01 5.80e-03 2.71e-01 AD_UKB_z3_5 Exclusive agegene_human Exclusive 2.92e-01 2.76e-01 6.20e-02 2.36e-41 agegene_human Exclusive AD_UKB_z3_5 Exclusive 5.94e-01 3.28e-01 3.05e-03 4.02e-01 AD_UKB_z3_5 Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 agegene_human Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 Overlap Exclusives 9.89e-02 8.15e-23 4.16e-128 3.04e-89 Evaluating how well AD_UKB_z3_5 genes are linked to agegene_human genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) AD_UKB_z3_5 Exclusive agegene_human 0.70 0.03 1.16 -0.45 11.20 agegene_human Exclusive AD_UKB_z3_5 0.57 2.92 0.59 0.74 1.10 AD_UKB_z3_5 Exclusive agegene_human Exclusive 0.70 -0.31 0.83 -0.50 12.41 agegene_human Exclusive AD_UKB_z3_5 Exclusive 0.54 3.36 0.74 0.88 0.55 AD_UKB_z3_5 Exclusive Overlap 1.00 2.10 460545094637691.50 1.75 1.54 agegene_human Exclusive Overlap 1.00 1.67 -10408024770435.00 0.99 1.78 Overlap Exclusives 0.82 -66673804883513.00 11.88 1.66 20.48 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) AD_UKB_z3_5 Exclusive agegene_human 0.03 0.15 2.05 -0.40 8.79 agegene_human Exclusive AD_UKB_z3_5 0.00 5.36 -0.63 0.71 0.57 AD_UKB_z3_5 Exclusive agegene_human Exclusive 0.02 -0.25 1.25 -0.46 9.12 agegene_human Exclusive AD_UKB_z3_5 Exclusive 0.00 4.03 0.41 0.28 -0.34 AD_UKB_z3_5 Exclusive Overlap 0.01 43.76 157276716155582336.00 13.20 22.80 agegene_human Exclusive Overlap 0.01 6.10 -1408187491747204.50 3.27 12.08 Overlap Exclusives 0.06 907899770093409.00 23.22 1.94 51.52 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes AD_UKB_z3_5 Exclusive 20 20 agegene_human Exclusive 306 304 TERC;TOPĀ 1.00 Overlap 1 1