Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wellderly_AD_UKB_z3_5 Exclusive	Kevin	2.87e-01	2.22e-01	8.56e-01	3.41e-01
Kevin Exclusive	Wellderly_AD_UKB_z3_5	7.05e-01	7.83e-01	7.08e-01	2.67e-01
Wellderly_AD_UKB_z3_5 Exclusive	Kevin Exclusive	4.63e-01	1.77e-01	7.74e-01	3.86e-01
Kevin Exclusive	Wellderly_AD_UKB_z3_5 Exclusive	8.78e-01	6.59e-01	9.27e-01	3.28e-01
Wellderly_AD_UKB_z3_5 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Kevin Exclusive	Overlap	2.18e-01	1.98e-02	5.94e-02	7.92e-02
Overlap	Exclusives	1.73e-01	7.01e-01	8.22e-26	5.18e-02



Evaluating how well Wellderly_AD_UKB_z3_5 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_AD_UKB_z3_5 Exclusive	Kevin	0.54	-0.52	-1.42	-0.39	1.32
Kevin Exclusive	Wellderly_AD_UKB_z3_5	0.58	0.11	0.76	0.99	1.84
Wellderly_AD_UKB_z3_5 Exclusive	Kevin Exclusive	0.53	-0.37	-1.49	-0.47	1.00
Kevin Exclusive	Wellderly_AD_UKB_z3_5 Exclusive	0.57	0.23	0.95	0.70	1.50
Wellderly_AD_UKB_z3_5 Exclusive	Overlap	1.00	1.12	654805977221702.00	1.38	1.66
Kevin Exclusive	Overlap	0.97	0.53	881225442216575.00	0.91	1.59
Overlap	Exclusives	0.57	-inf	0.22	0.44	2.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_AD_UKB_z3_5 Exclusive	Kevin	0.01	0.51	1.71	0.88	1.22
Kevin Exclusive	Wellderly_AD_UKB_z3_5	0.00	-0.32	0.01	0.47	0.07
Wellderly_AD_UKB_z3_5 Exclusive	Kevin Exclusive	0.01	0.16	0.51	0.41	0.76
Kevin Exclusive	Wellderly_AD_UKB_z3_5 Exclusive	0.00	-0.31	-0.12	0.04	0.51
Wellderly_AD_UKB_z3_5 Exclusive	Overlap	0.01	17.56	115050241542260128.00	37.65	41.83
Kevin Exclusive	Overlap	0.00	-0.13	20740945745735456.00	0.55	2.92
Overlap	Exclusives	0.02	3568544215766460.00	17.21	6.39	15.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wellderly_AD_UKB_z3_5 Exclusive	44	44	
Kevin Exclusive	79	76	KN3KRP;LINC02049;CDKN2B-AS1
Overlap	1	1