Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wellderly_UKB_z3_5	Kevin	3.54e-01	2.60e-01	2.97e-02	8.89e-02
Kevin	Wellderly_UKB_z3_5	4.69e-01	9.32e-01	9.98e-01	8.00e-01



Evaluating how well Wellderly_UKB_z3_5 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_UKB_z3_5	Kevin	0.54	-0.48	-1.43	-0.19	1.26
Kevin	Wellderly_UKB_z3_5	0.56	-0.83	-0.75	-0.18	0.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wellderly_UKB_z3_5	Kevin	0.00	-0.64	-1.55	-0.40	-0.08
Kevin	Wellderly_UKB_z3_5	0.00	-1.27	-0.94	-0.54	-0.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wellderly_UKB_z3_5	24	24	
Kevin	80	77	CDKN2B-AS1;LINC02049;KN3KRP