Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD_UKB_z3_5 Exclusive	Kevin	2.78e-01	4.21e-01	1.44e-01	3.66e-01
Kevin Exclusive	AD_UKB_z3_5	8.40e-01	5.74e-01	3.78e-01	3.35e-01
AD_UKB_z3_5 Exclusive	Kevin Exclusive	2.47e-01	3.33e-01	2.26e-01	3.97e-01
Kevin Exclusive	AD_UKB_z3_5 Exclusive	9.58e-01	4.47e-01	4.15e-01	4.18e-01
AD_UKB_z3_5 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Kevin Exclusive	Overlap	1.58e-01	1.98e-02	5.94e-02	7.92e-02
Overlap	Exclusives	2.37e-01	5.32e-01	2.02e-22	5.07e-02



Evaluating how well AD_UKB_z3_5 genes are linked to Kevin genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD_UKB_z3_5 Exclusive	Kevin	0.55	-0.43	-0.77	-0.44	1.46
Kevin Exclusive	AD_UKB_z3_5	0.60	1.14	1.65	1.38	1.64
AD_UKB_z3_5 Exclusive	Kevin Exclusive	0.54	-0.48	-1.07	-0.41	1.21
Kevin Exclusive	AD_UKB_z3_5 Exclusive	0.59	1.07	1.72	1.46	1.48
AD_UKB_z3_5 Exclusive	Overlap	1.00	1.78	460545094637691.50	1.61	1.64
Kevin Exclusive	Overlap	0.97	0.78	881225442216575.00	0.90	1.58
Overlap	Exclusives	0.58	-inf	1.38	0.74	2.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD_UKB_z3_5 Exclusive	Kevin	0.01	0.89	2.66	0.59	2.78
Kevin Exclusive	AD_UKB_z3_5	0.00	0.08	0.05	0.67	1.13
AD_UKB_z3_5 Exclusive	Kevin Exclusive	0.01	0.33	1.46	0.65	2.06
Kevin Exclusive	AD_UKB_z3_5 Exclusive	0.00	0.40	0.09	0.83	0.13
AD_UKB_z3_5 Exclusive	Overlap	0.01	40.72	157276716155582336.00	21.56	4.73
Kevin Exclusive	Overlap	0.00	0.10	20740945745735456.00	0.79	2.36
Overlap	Exclusives	0.02	17518004458811160.00	30.55	8.17	24.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD_UKB_z3_5 Exclusive	20	20	
Kevin Exclusive	79	76	KN3KRP;LINC02049;CDKN2B-AS1
Overlap	1	1