Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_ac1 Exclusive	wellderly_ac10	1.79e-02	3.31e-01	2.48e-02	4.74e-03
wellderly_ac10 Exclusive	wellderly_ac1	3.87e-02	1.25e-01	2.05e-03	3.54e-04
wellderly_ac1 Exclusive	wellderly_ac10 Exclusive	2.49e-02	6.29e-01	4.22e-02	9.08e-03
wellderly_ac10 Exclusive	wellderly_ac1 Exclusive	1.18e-01	5.51e-01	6.87e-02	2.00e-03
wellderly_ac1 Exclusive	Overlap	4.34e-05	7.48e-05	1.62e-05	2.48e-04
wellderly_ac10 Exclusive	Overlap	8.86e-06	1.08e-04	2.30e-07	8.48e-05
Overlap	Exclusives	6.71e-09	1.43e-08	2.75e-07	2.52e-15



Evaluating how well wellderly_ac1 genes are linked to wellderly_ac10 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac1 Exclusive	wellderly_ac10	0.58	-0.08	0.74	0.30	3.25
wellderly_ac10 Exclusive	wellderly_ac1	0.65	0.22	1.25	0.95	4.39
wellderly_ac1 Exclusive	wellderly_ac10 Exclusive	0.57	-0.23	-0.09	0.08	3.03
wellderly_ac10 Exclusive	wellderly_ac1 Exclusive	0.62	-0.34	0.28	0.16	3.18
wellderly_ac1 Exclusive	Overlap	0.98	2.99	4.10	3.07	3.27
wellderly_ac10 Exclusive	Overlap	0.95	2.47	3.41	2.74	3.06
Overlap	Exclusives	0.70	1.67	6.82	1.41	8.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac1 Exclusive	wellderly_ac10	0.01	2.92	7.00	4.73	7.16
wellderly_ac10 Exclusive	wellderly_ac1	0.01	0.65	3.34	2.48	6.93
wellderly_ac1 Exclusive	wellderly_ac10 Exclusive	0.01	1.83	3.06	2.42	7.12
wellderly_ac10 Exclusive	wellderly_ac1 Exclusive	0.01	0.46	1.22	1.10	0.99
wellderly_ac1 Exclusive	Overlap	0.02	20.09	0.38	63.58	32.84
wellderly_ac10 Exclusive	Overlap	0.00	3.09	5.32	3.58	3.70
Overlap	Exclusives	0.03	5.84	12.22	6.59	24.31

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_ac1 Exclusive	50	50	
wellderly_ac10 Exclusive	135	135	
Overlap	4	4