Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GenAge Exclusive	tier1_AD	6.59e-02	3.10e-01	8.79e-08	4.71e-03
tier1_AD Exclusive	GenAge	2.55e-05	2.08e-04	1.10e-05	3.16e-32
GenAge Exclusive	tier1_AD Exclusive	2.13e-01	5.24e-01	2.14e-06	4.06e-02
tier1_AD Exclusive	GenAge Exclusive	2.73e-05	1.54e-04	2.82e-05	1.04e-30
GenAge Exclusive	Overlap	4.36e-07	1.45e-01	4.36e-07	5.23e-05
tier1_AD Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	3.83e-11	4.00e-23	4.75e-90	1.65e-87



Evaluating how well GenAge genes are linked to tier1_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GenAge Exclusive	tier1_AD	0.67	3.18	1.27	1.13	2.97
tier1_AD Exclusive	GenAge	0.72	-0.43	3.30	0.32	13.61
GenAge Exclusive	tier1_AD Exclusive	0.63	3.01	0.51	0.73	2.43
tier1_AD Exclusive	GenAge Exclusive	0.71	-0.53	3.37	0.15	12.34
GenAge Exclusive	Overlap	0.98	2.92	1.44	1.83	2.68
tier1_AD Exclusive	Overlap	1.00	2.45	2.29	3.11	2.70
Overlap	Exclusives	0.83	1.60	10.67	1.97	19.87

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GenAge Exclusive	tier1_AD	0.00	5.93	0.70	2.33	3.23
tier1_AD Exclusive	GenAge	0.03	0.35	7.69	1.47	20.44
GenAge Exclusive	tier1_AD Exclusive	0.00	3.89	0.26	0.58	0.97
tier1_AD Exclusive	GenAge Exclusive	0.03	-0.06	6.45	0.91	16.41
GenAge Exclusive	Overlap	0.00	6.86	0.56	5.51	4.24
tier1_AD Exclusive	Overlap	0.05	78.41	143.79	205.38	14.90
Overlap	Exclusives	0.09	5.60	36.88	6.51	61.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GenAge Exclusive	304	303	TERC
tier1_AD Exclusive	28	27	MS4A
Overlap	3	3