Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
kw_aging Exclusive	tier1_AD	7.86e-01	1.66e-01	6.71e-02	5.79e-03
tier1_AD Exclusive	kw_aging	3.85e-04	1.02e-01	5.25e-02	7.26e-01
kw_aging Exclusive	tier1_AD Exclusive	6.80e-01	1.62e-01	9.63e-02	1.46e-02
tier1_AD Exclusive	kw_aging Exclusive	2.00e-04	6.95e-02	7.08e-02	6.76e-01
kw_aging Exclusive	Overlap	2.77e-01	1.98e-02	1.19e-01	7.92e-02
tier1_AD Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.88e-03	6.81e-04	1.89e-29	2.30e-05



Evaluating how well kw_aging genes are linked to tier1_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
kw_aging Exclusive	tier1_AD	0.65	0.56	1.11	0.91	3.26
tier1_AD Exclusive	kw_aging	0.51	-1.35	-2.15	-1.14	0.25
kw_aging Exclusive	tier1_AD Exclusive	0.63	0.58	1.13	0.80	2.48
tier1_AD Exclusive	kw_aging Exclusive	0.51	-1.54	-2.20	-1.06	-0.00
kw_aging Exclusive	Overlap	0.97	0.53	881225442216575.00	0.98	1.53
tier1_AD Exclusive	Overlap	1.00	1.28	inf	1.62	1.90
Overlap	Exclusives	0.65	139603361535173.00	3.86	2.18	5.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
kw_aging Exclusive	tier1_AD	0.00	0.14	0.39	0.49	2.58
tier1_AD Exclusive	kw_aging	0.01	0.59	2.02	0.55	2.24
kw_aging Exclusive	tier1_AD Exclusive	0.00	0.26	0.48	-0.00	1.22
tier1_AD Exclusive	kw_aging Exclusive	0.00	-0.10	0.15	0.10	1.01
kw_aging Exclusive	Overlap	0.00	-0.17	20740945745735456.00	0.28	1.34
tier1_AD Exclusive	Overlap	0.02	16.28	151272923003761312.00	74.13	68.64
Overlap	Exclusives	0.02	7078281144878778.00	19.32	12.88	11.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
kw_aging Exclusive	79	76	KN3KRP;LINC02049;CDKN2B-AS1
tier1_AD Exclusive	30	29	MS4A
Overlap	1	1