Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_ac1	ot_cogFuncMeas_set1	3.23e-02	2.92e-03	9.36e-05	2.71e-05
ot_cogFuncMeas_set1	wellderly_ac1	7.43e-02	5.42e-02	1.44e-03	2.27e-03



Evaluating how well wellderly_ac1 genes are linked to ot_cogFuncMeas_set1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac1	ot_cogFuncMeas_set1	0.71	3.00	3.94	2.50	5.08
ot_cogFuncMeas_set1	wellderly_ac1	0.63	0.54	1.64	0.74	3.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac1	ot_cogFuncMeas_set1	0.00	3.71	1.61	2.76	0.45
ot_cogFuncMeas_set1	wellderly_ac1	0.01	0.68	4.40	0.74	4.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_ac1	54	54	
ot_cogFuncMeas_set1	41	40	LINC02210-CRHR1