Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wellderly_ac10	ot_cogFuncMeas_set1	9.89e-04	5.19e-01	3.08e-01	7.80e-03
ot_cogFuncMeas_set1	wellderly_ac10	5.56e-01	7.61e-01	4.05e-01	1.00e-02



Evaluating how well wellderly_ac10 genes are linked to ot_cogFuncMeas_set1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac10	ot_cogFuncMeas_set1	0.60	-0.31	0.18	0.08	2.33
ot_cogFuncMeas_set1	wellderly_ac10	0.57	0.24	0.10	-0.18	2.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wellderly_ac10	ot_cogFuncMeas_set1	0.00	-0.42	-0.36	-0.33	0.22
ot_cogFuncMeas_set1	wellderly_ac10	0.01	-0.10	-0.71	-0.24	0.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wellderly_ac10	139	139	
ot_cogFuncMeas_set1	41	40	LINC02210-CRHR1