Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UD Exclusive	GS tier1	7.60e-02	2.21e-01	6.71e-02	1.09e-03
GS tier1 Exclusive	UD	2.16e-02	4.38e-01	5.39e-01	3.40e-01
UD Exclusive	GS tier1 Exclusive	1.17e-01	2.13e-01	7.29e-02	3.44e-03
GS tier1 Exclusive	UD Exclusive	1.50e-02	3.31e-01	4.19e-01	4.11e-01
UD Exclusive	Overlap	9.55e-01	7.49e-01	7.40e-01	2.89e-01
GS tier1 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	4.32e-04	2.05e-05	6.84e-16	4.21e-07



Evaluating how well UD genes are linked to GS tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UD Exclusive	GS tier1	0.64	1.17	1.06	0.67	3.27
GS tier1 Exclusive	UD	0.53	-0.56	-0.35	-0.14	0.82
UD Exclusive	GS tier1 Exclusive	0.63	1.05	1.08	0.83	2.67
GS tier1 Exclusive	UD Exclusive	0.51	-1.02	-0.71	-0.66	0.30
UD Exclusive	Overlap	0.73	0.22	-0.01	0.52	1.46
GS tier1 Exclusive	Overlap	1.00	3.04	2.74	2.66	2.90
Overlap	Exclusives	0.66	4.18	5.37	3.61	5.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UD Exclusive	GS tier1	0.00	-0.05	-0.47	-0.13	0.40
GS tier1 Exclusive	UD	0.01	3.38	8.73	8.19	8.83
UD Exclusive	GS tier1 Exclusive	0.00	-0.06	-0.23	-0.08	0.23
GS tier1 Exclusive	UD Exclusive	0.00	-0.45	-0.10	-0.16	0.11
UD Exclusive	Overlap	0.00	-0.20	-1.66	-0.21	-0.04
GS tier1 Exclusive	Overlap	0.10	404.88	139.75	214.07	200.87
Overlap	Exclusives	0.06	59.86	95.65	51.49	107.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UD Exclusive	80	79	C11orf97
GS tier1 Exclusive	28	27	MS4A
Overlap	3	3