Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UD	GS tier 2	3.20e-01	6.59e-02	3.00e-02	9.42e-04
GS tier 2	UD	8.84e-01	9.71e-01	1.46e-01	5.39e-01



Evaluating how well UD genes are linked to GS tier 2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UD	GS tier 2	0.67	1.50	2.61	2.16	4.28
GS tier 2	UD	0.54	0.19	0.27	0.33	1.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UD	GS tier 2	0.00	1.55	2.46	2.18	3.84
GS tier 2	UD	0.02	29.72	24.45	28.20	24.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UD	83	82	C11orf97
GS tier 2	46	43	TNSF12;IGH;TNSF13