Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
VD	Ismael	1.12e-01	3.00e-01	7.53e-02	4.94e-03
Ismael	VD	1.18e-03	6.31e-01	1.11e-02	8.48e-01



Evaluating how well VD genes are linked to Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
VD	Ismael	0.76	1.25	1.29	1.11	3.30
Ismael	VD	0.51	-1.10	-0.69	-0.38	0.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
VD	Ismael	0.00	2.72	2.28	1.62	0.85
Ismael	VD	0.00	0.61	1.50	1.19	1.31

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
VD	75	74	AL031777.3
Ismael	14	14