Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
selected_2_AD_79_56	tier2_gs	1.26e-01	7.90e-03	8.28e-02	6.92e-04
tier2_gs	selected_2_AD_79_56	1.64e-01	4.21e-01	7.11e-02	3.13e-01



Evaluating how well selected_2_AD_79_56 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_AD_79_56	tier2_gs	0.70	1.99	4.07	2.76	4.62
tier2_gs	selected_2_AD_79_56	0.54	1.65	1.10	1.09	0.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_AD_79_56	tier2_gs	0.00	0.51	5.27	2.74	3.71
tier2_gs	selected_2_AD_79_56	0.02	33.86	20.97	27.75	38.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
selected_2_AD_79_56	56	55	EDDM13
tier2_gs	46	43	TNSF13;TNSF12;IGH