Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
selected_2_AD_79_136 Exclusive	tier1_31	6.14e-10	1.28e-09	3.42e-10	1.56e-11
tier1_31 Exclusive	selected_2_AD_79_136	2.36e-01	7.33e-01	2.55e-01	5.04e-01
selected_2_AD_79_136 Exclusive	tier1_31 Exclusive	2.56e-07	4.44e-08	4.56e-08	2.00e-08
tier1_31 Exclusive	selected_2_AD_79_136 Exclusive	3.34e-02	5.90e-01	3.79e-01	5.34e-01
selected_2_AD_79_136 Exclusive	Overlap	4.57e-04	8.41e-03	1.16e-03	3.21e-05
tier1_31 Exclusive	Overlap	1.83e-09	3.84e-07	9.14e-09	2.74e-08
Overlap	Exclusives	2.62e-04	6.22e-05	4.48e-14	5.21e-05



Evaluating how well selected_2_AD_79_136 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_AD_79_136 Exclusive	tier1_31	0.86	4.31	6.53	4.39	6.65
tier1_31 Exclusive	selected_2_AD_79_136	0.53	0.64	0.33	0.78	1.22
selected_2_AD_79_136 Exclusive	tier1_31 Exclusive	0.84	3.29	5.79	3.75	5.79
tier1_31 Exclusive	selected_2_AD_79_136 Exclusive	0.52	-0.24	0.02	0.12	0.46
selected_2_AD_79_136 Exclusive	Overlap	0.98	3.27	3.60	3.29	4.06
tier1_31 Exclusive	Overlap	1.00	3.60	2.99	2.93	3.48
Overlap	Exclusives	0.61	3.94	5.25	4.17	4.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_AD_79_136 Exclusive	tier1_31	0.03	50.99	87.55	35.82	54.17
tier1_31 Exclusive	selected_2_AD_79_136	0.03	36.06	45.80	43.49	45.40
selected_2_AD_79_136 Exclusive	tier1_31 Exclusive	0.02	25.40	70.47	35.73	30.83
tier1_31 Exclusive	selected_2_AD_79_136 Exclusive	0.02	23.88	27.95	29.20	24.84
selected_2_AD_79_136 Exclusive	Overlap	0.01	41.29	41.55	25.20	5.40
tier1_31 Exclusive	Overlap	0.08	353.97	112.03	244.09	261.26
Overlap	Exclusives	0.07	84.25	90.90	89.81	92.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
selected_2_AD_79_136 Exclusive	132	129	EDDM13;CHURC1-FNTB;AC093155.3
tier1_31 Exclusive	27	26	MS4A
Overlap	4	4