Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Regulome_selected_2_AD_79_74	tier2_gs	3.31e-02	4.67e-02	3.14e-02	4.33e-04
tier2_gs	Regulome_selected_2_AD_79_74	1.65e-01	1.30e-01	5.10e-03	1.36e-01



Evaluating how well Regulome_selected_2_AD_79_74 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_selected_2_AD_79_74	tier2_gs	0.66	1.91	2.33	1.85	3.74
tier2_gs	Regulome_selected_2_AD_79_74	0.56	2.13	2.18	2.07	1.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_selected_2_AD_79_74	tier2_gs	0.00	1.85	3.46	1.93	4.17
tier2_gs	Regulome_selected_2_AD_79_74	0.00	1.81	1.20	2.71	0.45

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Regulome_selected_2_AD_79_74	74	70	TMEM191C;PRAMEF15;AL451062.3;AC005779.2
tier2_gs	46	43	TNSF13;IGH;TNSF12