Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
R4 Exclusive	AD_UKB	1.29e-01	1.06e-01	2.57e-01	3.71e-03
AD_UKB Exclusive	R4	5.68e-02	5.85e-02	5.65e-03	8.27e-02
R4 Exclusive	AD_UKB Exclusive	1.91e-01	1.18e-01	3.80e-01	1.87e-02
AD_UKB Exclusive	R4 Exclusive	1.61e-01	1.55e-01	8.86e-03	2.39e-01
R4 Exclusive	Overlap	1.72e-02	7.27e-02	2.51e-02	1.04e-02
AD_UKB Exclusive	Overlap	3.54e-01	3.59e-01	2.84e-01	3.80e-01
Overlap	Exclusives	1.56e-01	2.90e-01	3.81e-02	6.94e-02



Evaluating how well R4 genes are linked to AD_UKB genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
R4 Exclusive	AD_UKB	0.58	2.45	1.71	1.85	2.79
AD_UKB Exclusive	R4	0.54	1.53	1.97	1.61	1.63
R4 Exclusive	AD_UKB Exclusive	0.57	1.82	1.55	1.45	2.26
AD_UKB Exclusive	R4 Exclusive	0.53	1.20	1.31	1.39	1.00
R4 Exclusive	Overlap	0.68	1.85	1.47	1.62	1.90
AD_UKB Exclusive	Overlap	0.65	1.45	1.37	1.40	1.41
Overlap	Exclusives	0.55	-0.10	1.63	1.38	2.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
R4 Exclusive	AD_UKB	0.01	1.36	0.72	0.98	1.23
AD_UKB Exclusive	R4	0.01	0.64	0.37	0.43	0.21
R4 Exclusive	AD_UKB Exclusive	0.01	0.50	0.55	0.10	0.42
AD_UKB Exclusive	R4 Exclusive	0.01	0.24	0.02	0.13	0.10
R4 Exclusive	Overlap	0.00	2.29	0.59	0.89	3.86
AD_UKB Exclusive	Overlap	0.00	0.02	-0.32	0.05	0.12
Overlap	Exclusives	0.01	0.24	2.18	1.96	1.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
R4 Exclusive	109	106	10-Mar;EDDM13;CHURC1-FNTB
AD_UKB Exclusive	94	94	
Overlap	7	7