Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD_R2 Exclusive	AD_UKB	4.30e-01	5.65e-01	1.58e-01	1.35e-01
AD_UKB Exclusive	AD_R2	9.87e-01	9.51e-01	5.40e-01	3.36e-01
AD_R2 Exclusive	AD_UKB Exclusive	7.87e-01	9.44e-01	4.55e-01	4.28e-01
AD_UKB Exclusive	AD_R2 Exclusive	9.06e-01	6.95e-01	7.06e-01	6.45e-01
AD_R2 Exclusive	Overlap	8.73e-02	4.31e-02	8.31e-03	1.88e-03
AD_UKB Exclusive	Overlap	1.38e-01	2.63e-01	7.12e-02	3.04e-02
Overlap	Exclusives	3.38e-01	2.85e-01	3.69e-08	2.83e-03



Evaluating how well AD_R2 genes are linked to AD_UKB genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD_R2 Exclusive	AD_UKB	0.56	0.34	1.09	0.81	2.01
AD_UKB Exclusive	AD_R2	0.54	0.19	0.02	0.44	2.16
AD_R2 Exclusive	AD_UKB Exclusive	0.53	-0.09	0.15	-0.14	1.12
AD_UKB Exclusive	AD_R2 Exclusive	0.53	-0.25	-0.62	-0.10	1.01
AD_R2 Exclusive	Overlap	0.88	2.69	3.79	2.74	3.37
AD_UKB Exclusive	Overlap	0.76	1.65	1.77	2.01	2.36
Overlap	Exclusives	0.57	1.53	2.00	1.97	3.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD_R2 Exclusive	AD_UKB	0.01	1.95	1.38	1.89	2.97
AD_UKB Exclusive	AD_R2	0.01	0.86	0.83	1.25	3.00
AD_R2 Exclusive	AD_UKB Exclusive	0.01	0.48	0.25	0.68	0.46
AD_UKB Exclusive	AD_R2 Exclusive	0.01	0.55	0.65	0.13	0.92
AD_R2 Exclusive	Overlap	0.00	5.72	6.65	4.45	2.17
AD_UKB Exclusive	Overlap	0.00	1.00	-0.15	0.95	0.09
Overlap	Exclusives	0.02	3.74	2.50	3.81	3.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD_R2 Exclusive	115	114	RFPL2
AD_UKB Exclusive	94	94	
Overlap	7	7