Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB470K_Case_wKS Exclusive	AoU_Case_wKS	1.29e-02	3.57e-02	2.21e-07	2.64e-07
AoU_Case_wKS Exclusive	UKB470K_Case_wKS	5.84e-02	4.94e-01	1.77e-04	1.00e-05
UKB470K_Case_wKS Exclusive	AoU_Case_wKS Exclusive	1.21e-01	1.16e-01	2.03e-04	1.66e-05
AoU_Case_wKS Exclusive	UKB470K_Case_wKS Exclusive	3.15e-02	6.29e-01	1.13e-03	2.87e-05
UKB470K_Case_wKS Exclusive	Overlap	5.12e-10	7.90e-07	4.27e-10	4.57e-09
AoU_Case_wKS Exclusive	Overlap	3.05e-02	9.35e-02	5.74e-04	1.50e-03
Overlap	Exclusives	1.38e-09	5.57e-02	1.60e-09	2.18e-07



Evaluating how well UKB470K_Case_wKS genes are linked to AoU_Case_wKS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB470K_Case_wKS Exclusive	AoU_Case_wKS	0.67	1.12	2.93	2.36	5.96
AoU_Case_wKS Exclusive	UKB470K_Case_wKS	0.63	1.29	1.63	1.16	5.13
UKB470K_Case_wKS Exclusive	AoU_Case_wKS Exclusive	0.64	0.44	2.13	1.55	4.51
AoU_Case_wKS Exclusive	UKB470K_Case_wKS Exclusive	0.62	1.09	1.26	1.30	5.65
UKB470K_Case_wKS Exclusive	Overlap	0.97	2.56	4.03	2.36	4.95
AoU_Case_wKS Exclusive	Overlap	0.81	1.17	1.99	1.09	3.46
Overlap	Exclusives	0.62	-0.50	0.83	0.24	5.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB470K_Case_wKS Exclusive	AoU_Case_wKS	0.01	0.74	4.70	3.24	6.81
AoU_Case_wKS Exclusive	UKB470K_Case_wKS	0.01	-0.21	0.83	0.82	5.33
UKB470K_Case_wKS Exclusive	AoU_Case_wKS Exclusive	0.01	-0.53	1.10	0.89	1.17
AoU_Case_wKS Exclusive	UKB470K_Case_wKS Exclusive	0.01	-0.21	0.46	0.93	4.92
UKB470K_Case_wKS Exclusive	Overlap	0.01	3.71	20.18	6.77	4.61
AoU_Case_wKS Exclusive	Overlap	0.00	0.44	1.28	0.84	3.51
Overlap	Exclusives	0.03	3.22	11.07	5.18	12.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB470K_Case_wKS Exclusive	162	162	
AoU_Case_wKS Exclusive	101	99	TUBA4B;GK3P
Overlap	10	10