Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB470K_Cases_AC1_FullPathGenes Exclusive	AoU_Cases_AC1_FullPathGenes	2.18e-04	3.25e-02	7.67e-12	1.99e-10
AoU_Cases_AC1_FullPathGenes Exclusive	UKB470K_Cases_AC1_FullPathGenes	2.97e-04	3.47e-02	4.74e-12	4.43e-14
UKB470K_Cases_AC1_FullPathGenes Exclusive	AoU_Cases_AC1_FullPathGenes Exclusive	5.78e-04	4.56e-01	5.19e-06	3.07e-06
AoU_Cases_AC1_FullPathGenes Exclusive	UKB470K_Cases_AC1_FullPathGenes Exclusive	1.53e-04	6.20e-02	1.40e-08	3.76e-12
UKB470K_Cases_AC1_FullPathGenes Exclusive	Overlap	5.47e-24	6.60e-17	7.69e-39	1.76e-21
AoU_Cases_AC1_FullPathGenes Exclusive	Overlap	6.17e-05	1.24e-04	7.89e-11	2.49e-11
Overlap	Exclusives	1.39e-11	8.50e-04	7.66e-07	6.54e-19



Evaluating how well UKB470K_Cases_AC1_FullPathGenes genes are linked to AoU_Cases_AC1_FullPathGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB470K_Cases_AC1_FullPathGenes Exclusive	AoU_Cases_AC1_FullPathGenes	0.65	0.39	2.58	1.91	7.67
AoU_Cases_AC1_FullPathGenes Exclusive	UKB470K_Cases_AC1_FullPathGenes	0.63	1.22	2.61	1.85	9.39
UKB470K_Cases_AC1_FullPathGenes Exclusive	AoU_Cases_AC1_FullPathGenes Exclusive	0.61	-0.61	0.73	0.75	4.58
AoU_Cases_AC1_FullPathGenes Exclusive	UKB470K_Cases_AC1_FullPathGenes Exclusive	0.62	1.06	1.94	1.47	7.76
UKB470K_Cases_AC1_FullPathGenes Exclusive	Overlap	0.99	2.50	7.02	3.44	6.96
AoU_Cases_AC1_FullPathGenes Exclusive	Overlap	0.89	1.86	4.51	1.85	6.73
Overlap	Exclusives	0.64	1.77	4.09	1.39	12.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB470K_Cases_AC1_FullPathGenes Exclusive	AoU_Cases_AC1_FullPathGenes	0.02	1.57	7.73	4.66	15.12
AoU_Cases_AC1_FullPathGenes Exclusive	UKB470K_Cases_AC1_FullPathGenes	0.03	-0.62	0.92	1.25	7.32
UKB470K_Cases_AC1_FullPathGenes Exclusive	AoU_Cases_AC1_FullPathGenes Exclusive	0.01	-1.35	0.27	0.52	2.55
AoU_Cases_AC1_FullPathGenes Exclusive	UKB470K_Cases_AC1_FullPathGenes Exclusive	0.02	-0.83	-0.22	0.66	5.39
UKB470K_Cases_AC1_FullPathGenes Exclusive	Overlap	0.04	13.03	48.90	38.67	66.70
AoU_Cases_AC1_FullPathGenes Exclusive	Overlap	0.01	1.01	11.33	3.03	4.54
Overlap	Exclusives	0.06	5.13	18.89	7.37	29.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB470K_Cases_AC1_FullPathGenes Exclusive	336	336	
AoU_Cases_AC1_FullPathGenes Exclusive	177	174	GK3P;TUBB3;TUBA4B
Overlap	19	19