Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB470K_Cases_AC1_FullPathGenes Exclusive	AoU_Cases_AC1_FullPathGenes	7.23e-06	1.38e-02	1.23e-14	6.21e-12
AoU_Cases_AC1_FullPathGenes Exclusive	UKB470K_Cases_AC1_FullPathGenes	2.39e-05	3.49e-04	8.11e-13	8.07e-22
UKB470K_Cases_AC1_FullPathGenes Exclusive	AoU_Cases_AC1_FullPathGenes Exclusive	3.49e-04	8.59e-01	1.70e-06	1.62e-06
AoU_Cases_AC1_FullPathGenes Exclusive	UKB470K_Cases_AC1_FullPathGenes Exclusive	2.31e-05	1.76e-03	5.75e-10	1.81e-17
UKB470K_Cases_AC1_FullPathGenes Exclusive	Overlap	8.93e-26	2.61e-21	2.07e-28	1.40e-24
AoU_Cases_AC1_FullPathGenes Exclusive	Overlap	2.31e-03	1.48e-03	1.07e-08	1.15e-10
Overlap	Exclusives	2.33e-19	1.41e-02	2.56e-10	1.98e-17



Evaluating how well UKB470K_Cases_AC1_FullPathGenes genes are linked to AoU_Cases_AC1_FullPathGenes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB470K_Cases_AC1_FullPathGenes Exclusive	AoU_Cases_AC1_FullPathGenes	0.66	0.96	2.89	2.28	7.67
AoU_Cases_AC1_FullPathGenes Exclusive	UKB470K_Cases_AC1_FullPathGenes	0.63	1.40	2.83	2.14	9.11
UKB470K_Cases_AC1_FullPathGenes Exclusive	AoU_Cases_AC1_FullPathGenes Exclusive	0.61	-0.21	0.26	0.86	5.93
AoU_Cases_AC1_FullPathGenes Exclusive	UKB470K_Cases_AC1_FullPathGenes Exclusive	0.62	1.30	2.44	1.83	8.94
UKB470K_Cases_AC1_FullPathGenes Exclusive	Overlap	0.97	3.39	7.86	3.10	9.91
AoU_Cases_AC1_FullPathGenes Exclusive	Overlap	0.84	1.22	4.23	1.54	6.70
Overlap	Exclusives	0.63	1.98	2.76	1.33	11.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB470K_Cases_AC1_FullPathGenes Exclusive	AoU_Cases_AC1_FullPathGenes	0.03	1.37	7.33	5.19	15.41
AoU_Cases_AC1_FullPathGenes Exclusive	UKB470K_Cases_AC1_FullPathGenes	0.03	-1.50	0.69	0.96	7.05
UKB470K_Cases_AC1_FullPathGenes Exclusive	AoU_Cases_AC1_FullPathGenes Exclusive	0.01	-1.89	-0.65	-0.02	4.85
AoU_Cases_AC1_FullPathGenes Exclusive	UKB470K_Cases_AC1_FullPathGenes Exclusive	0.03	-1.96	-0.26	0.64	4.77
UKB470K_Cases_AC1_FullPathGenes Exclusive	Overlap	0.04	16.19	30.03	23.61	76.20
AoU_Cases_AC1_FullPathGenes Exclusive	Overlap	0.01	0.12	4.93	0.98	3.35
Overlap	Exclusives	0.06	5.33	13.46	6.61	24.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB470K_Cases_AC1_FullPathGenes Exclusive	424	420	GSTT2;GGT3P;E;GSTT1
AoU_Cases_AC1_FullPathGenes Exclusive	200	197	GK3P;TUBB3;TUBA4B
Overlap	29	29