Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LBD_sigma_genes Exclusive	ad_tier1_31	1.03e-01	2.33e-01	3.70e-01	4.84e-03
ad_tier1_31 Exclusive	LBD_sigma_genes	1.15e-02	7.64e-01	2.82e-01	7.85e-01
LBD_sigma_genes Exclusive	ad_tier1_31 Exclusive	2.23e-01	1.94e-01	2.70e-01	6.43e-03
ad_tier1_31 Exclusive	LBD_sigma_genes Exclusive	2.24e-02	6.69e-01	3.21e-01	6.13e-01
LBD_sigma_genes Exclusive	Overlap	4.95e-01	1.98e-02	7.92e-01	5.94e-02
ad_tier1_31 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	4.28e-05	5.80e-04	3.91e-68	7.61e-05



Evaluating how well LBD_sigma_genes genes are linked to ad_tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_sigma_genes Exclusive	ad_tier1_31	0.66	1.28	1.72	0.82	2.88
ad_tier1_31 Exclusive	LBD_sigma_genes	0.50	0.22	0.16	0.15	0.19
LBD_sigma_genes Exclusive	ad_tier1_31 Exclusive	0.65	0.93	2.12	0.80	2.45
ad_tier1_31 Exclusive	LBD_sigma_genes Exclusive	0.50	0.35	0.13	-0.03	-0.11
LBD_sigma_genes Exclusive	Overlap	0.98	0.82	128922979459803.00	0.61	1.53
ad_tier1_31 Exclusive	Overlap	1.00	1.26	inf	1.54	1.67
Overlap	Exclusives	0.58	144059224205907.00	5.63	2.95	3.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LBD_sigma_genes Exclusive	ad_tier1_31	0.00	0.37	0.61	-0.02	0.66
ad_tier1_31 Exclusive	LBD_sigma_genes	0.01	0.72	0.83	0.52	0.28
LBD_sigma_genes Exclusive	ad_tier1_31 Exclusive	0.00	0.14	1.02	-0.03	0.01
ad_tier1_31 Exclusive	LBD_sigma_genes Exclusive	0.01	0.21	0.07	-0.10	-0.22
LBD_sigma_genes Exclusive	Overlap	0.00	0.31	4051876407858447.00	-0.13	1.68
ad_tier1_31 Exclusive	Overlap	0.02	28.19	151272923003761312.00	66.00	28.47
Overlap	Exclusives	0.02	1350442052848551.75	7.30	5.06	7.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LBD_sigma_genes Exclusive	200	200	
ad_tier1_31 Exclusive	30	29	MS4A
Overlap	1	1