Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_ad_122	Juan_gene_20	5.10e-01	3.89e-01	2.68e-01	2.26e-02
Juan_gene_20	sigma_ad_122	9.93e-01	6.76e-01	2.88e-03	1.32e-01



Evaluating how well sigma_ad_122 genes are linked to Juan_gene_20 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_ad_122	Juan_gene_20	0.67	0.35	-0.64	0.45	2.38
Juan_gene_20	sigma_ad_122	0.56	0.24	1.06	1.15	2.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_ad_122	Juan_gene_20	0.00	0.62	0.02	1.51	0.47
Juan_gene_20	sigma_ad_122	0.01	-0.20	0.82	0.75	0.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_ad_122	122	121	RFPL2
Juan_gene_20	20	20