Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_ad_122 Exclusive	LBD_Sigma_201	4.68e-01	6.85e-01	3.81e-01	5.49e-01
LBD_Sigma_201 Exclusive	sigma_ad_122	2.97e-01	4.93e-01	2.00e-01	4.26e-01
sigma_ad_122 Exclusive	LBD_Sigma_201 Exclusive	3.92e-01	7.47e-01	7.17e-01	5.83e-01
LBD_Sigma_201 Exclusive	sigma_ad_122 Exclusive	2.87e-01	6.16e-01	3.20e-01	3.45e-01
sigma_ad_122 Exclusive	Overlap	5.96e-01	5.79e-01	3.62e-01	3.48e-01
LBD_Sigma_201 Exclusive	Overlap	6.05e-01	4.62e-01	4.70e-01	8.49e-01
Overlap	Exclusives	2.49e-03	1.06e-01	6.03e-23	1.43e-02



Evaluating how well sigma_ad_122 genes are linked to LBD_Sigma_201 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_ad_122 Exclusive	LBD_Sigma_201	0.50	-0.05	-0.67	-0.28	-0.35
LBD_Sigma_201 Exclusive	sigma_ad_122	0.52	-0.75	-0.54	-0.72	0.86
sigma_ad_122 Exclusive	LBD_Sigma_201 Exclusive	0.49	-0.17	-0.46	-0.48	-0.35
LBD_Sigma_201 Exclusive	sigma_ad_122 Exclusive	0.53	-0.79	-0.22	-0.47	1.22
sigma_ad_122 Exclusive	Overlap	0.69	1.06	1.44	1.11	1.14
LBD_Sigma_201 Exclusive	Overlap	0.48	-0.87	-1.09	-1.19	0.01
Overlap	Exclusives	0.55	1.62	2.70	2.40	3.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_ad_122 Exclusive	LBD_Sigma_201	0.01	0.15	-0.46	0.07	-0.30
LBD_Sigma_201 Exclusive	sigma_ad_122	0.01	-0.95	-0.42	-1.01	0.18
sigma_ad_122 Exclusive	LBD_Sigma_201 Exclusive	0.01	-0.03	-0.46	-0.46	-0.49
LBD_Sigma_201 Exclusive	sigma_ad_122 Exclusive	0.01	-1.19	-0.28	-0.76	0.11
sigma_ad_122 Exclusive	Overlap	0.00	10.14	1.75	11.55	2.49
LBD_Sigma_201 Exclusive	Overlap	0.00	-0.19	-0.36	-0.29	0.20
Overlap	Exclusives	0.02	1.08	1.63	1.82	2.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_ad_122 Exclusive	118	117	RFPL2
LBD_Sigma_201 Exclusive	197	197	
Overlap	4	4