Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_LBD_201 Exclusive	Juan_21	1.34e-01	1.55e-01	1.52e-01	3.38e-03
Juan_21 Exclusive	Sigma_LBD_201	5.74e-01	1.78e-01	2.21e-08	1.45e-01
Sigma_LBD_201 Exclusive	Juan_21 Exclusive	1.72e-01	3.54e-01	3.74e-01	7.55e-03
Juan_21 Exclusive	Sigma_LBD_201 Exclusive	5.18e-01	1.06e-01	6.76e-09	1.46e-01
Sigma_LBD_201 Exclusive	Overlap	1.98e-01	1.98e-02	2.38e-01	9.90e-02
Juan_21 Exclusive	Overlap	9.11e-01	7.92e-01	5.94e-01	2.77e-01
Overlap	Exclusives	3.01e-05	4.87e-02	1.38e-28	4.48e-03



Evaluating how well Sigma_LBD_201 genes are linked to Juan_21 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_LBD_201 Exclusive	Juan_21	0.72	1.84	1.69	1.62	3.21
Juan_21 Exclusive	Sigma_LBD_201	0.53	2.17	1.92	1.88	1.45
Sigma_LBD_201 Exclusive	Juan_21 Exclusive	0.71	1.46	1.51	1.27	3.53
Juan_21 Exclusive	Sigma_LBD_201 Exclusive	0.53	1.98	2.17	1.70	1.38
Sigma_LBD_201 Exclusive	Overlap	0.93	1.27	1.66	1.27	1.69
Juan_21 Exclusive	Overlap	0.75	-0.01	0.36	0.21	1.13
Overlap	Exclusives	0.53	1.03	0.99	0.93	1.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_LBD_201 Exclusive	Juan_21	0.00	1.81	1.54	0.97	1.29
Juan_21 Exclusive	Sigma_LBD_201	0.01	1.10	1.77	1.19	0.69
Sigma_LBD_201 Exclusive	Juan_21 Exclusive	0.00	1.02	0.84	0.56	0.36
Juan_21 Exclusive	Sigma_LBD_201 Exclusive	0.01	0.83	0.98	0.95	0.83
Sigma_LBD_201 Exclusive	Overlap	0.00	0.22	3.42	0.63	2.48
Juan_21 Exclusive	Overlap	0.00	-0.32	-0.22	-0.30	0.03
Overlap	Exclusives	0.01	1.41	0.91	0.81	1.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_LBD_201 Exclusive	200	200	
Juan_21 Exclusive	20	20	
Overlap	1	1