Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_ad_122	Juan_21	5.06e-01	8.02e-01	2.59e-01	1.15e-02
Juan_21	sigma_ad_122	9.72e-01	3.95e-01	3.72e-03	1.36e-01



Evaluating how well sigma_ad_122 genes are linked to Juan_21 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_ad_122	Juan_21	0.67	0.65	-0.30	0.68	2.36
Juan_21	sigma_ad_122	0.56	0.57	1.54	1.33	2.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_ad_122	Juan_21	0.00	1.05	0.24	1.39	1.18
Juan_21	sigma_ad_122	0.01	0.14	1.39	0.96	0.74

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_ad_122	122	121	RFPL2
Juan_21	21	21