Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_LBD_z_3_5	AD_Ismael	2.57e-03	2.58e-04	3.84e-04	7.87e-06
AD_Ismael	sigma_LBD_z_3_5	3.66e-01	7.09e-01	6.54e-04	1.92e-01



Evaluating how well sigma_LBD_z_3_5 genes are linked to AD_Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_LBD_z_3_5	AD_Ismael	0.81	1.86	2.99	1.69	3.84
AD_Ismael	sigma_LBD_z_3_5	0.55	1.51	0.72	0.81	1.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_LBD_z_3_5	AD_Ismael	0.00	1.38	3.07	2.36	4.54
AD_Ismael	sigma_LBD_z_3_5	0.01	0.60	2.35	2.41	2.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_LBD_z_3_5	81	81	
AD_Ismael	14	14