Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_LBD_z_3_5 Exclusive	LBD_GS	9.42e-01	2.34e-01	9.92e-01	8.34e-02
LBD_GS Exclusive	sigma_LBD_z_3_5	1.66e-01	9.13e-01	9.31e-24	2.34e-01
sigma_LBD_z_3_5 Exclusive	LBD_GS Exclusive	9.97e-01	6.89e-01	9.52e-01	7.06e-02
LBD_GS Exclusive	sigma_LBD_z_3_5 Exclusive	1.58e-01	9.42e-01	9.07e-23	3.32e-01
sigma_LBD_z_3_5 Exclusive	Overlap	8.72e-01	3.43e-01	9.46e-01	1.63e-01
LBD_GS Exclusive	Overlap	1.48e-03	9.85e-05	9.85e-04	9.85e-04
Overlap	Exclusives	1.10e-02	5.89e-02	4.61e-21	7.56e-03



Evaluating how well sigma_LBD_z_3_5 genes are linked to LBD_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_LBD_z_3_5 Exclusive	LBD_GS	0.74	-0.32	-0.33	0.18	2.07
LBD_GS Exclusive	sigma_LBD_z_3_5	0.55	-0.95	0.56	0.96	1.23
sigma_LBD_z_3_5 Exclusive	LBD_GS Exclusive	0.71	-0.48	-0.13	0.21	1.63
LBD_GS Exclusive	sigma_LBD_z_3_5 Exclusive	0.54	-1.46	0.42	0.69	1.13
sigma_LBD_z_3_5 Exclusive	Overlap	0.79	-0.31	-0.12	-0.08	1.58
LBD_GS Exclusive	Overlap	0.99	2.98	2.75	2.34	2.37
Overlap	Exclusives	0.60	3.95	3.52	2.34	3.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_LBD_z_3_5 Exclusive	LBD_GS	0.00	-0.51	-2.95	-0.11	0.04
LBD_GS Exclusive	sigma_LBD_z_3_5	0.01	0.66	0.96	1.33	0.37
sigma_LBD_z_3_5 Exclusive	LBD_GS Exclusive	0.00	-0.47	-2.15	0.05	3.14
LBD_GS Exclusive	sigma_LBD_z_3_5 Exclusive	0.00	-0.63	-0.28	0.15	0.57
sigma_LBD_z_3_5 Exclusive	Overlap	0.00	-0.39	-1.05	-0.44	0.21
LBD_GS Exclusive	Overlap	0.01	28.11	72.63	35.43	28.96
Overlap	Exclusives	0.01	2.06	1.83	1.53	3.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_LBD_z_3_5 Exclusive	79	79	
LBD_GS Exclusive	4	4	
Overlap	2	2