Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_LBD_z_3_5 Exclusive	Juan_21	8.50e-01	9.42e-01	3.43e-01	3.25e-02
Juan_21 Exclusive	sigma_LBD_z_3_5	6.71e-01	8.20e-01	3.92e-03	2.22e-01
sigma_LBD_z_3_5 Exclusive	Juan_21 Exclusive	9.65e-01	8.86e-01	5.17e-01	3.21e-02
Juan_21 Exclusive	sigma_LBD_z_3_5 Exclusive	5.45e-01	8.30e-01	9.42e-04	2.84e-01
sigma_LBD_z_3_5 Exclusive	Overlap	5.54e-01	1.98e-02	6.73e-01	3.37e-01
Juan_21 Exclusive	Overlap	1.00e+00	7.13e-01	5.15e-01	5.35e-01
Overlap	Exclusives	1.53e-03	3.01e-01	3.54e-16	6.68e-03



Evaluating how well sigma_LBD_z_3_5 genes are linked to Juan_21 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_LBD_z_3_5 Exclusive	Juan_21	0.66	0.35	0.18	0.82	2.65
Juan_21 Exclusive	sigma_LBD_z_3_5	0.53	-0.05	0.52	0.19	0.81
sigma_LBD_z_3_5 Exclusive	Juan_21 Exclusive	0.65	-0.09	0.05	0.57	2.40
Juan_21 Exclusive	sigma_LBD_z_3_5 Exclusive	0.53	-0.33	0.42	0.28	0.91
sigma_LBD_z_3_5 Exclusive	Overlap	0.83	0.85	1.61	0.63	1.15
Juan_21 Exclusive	Overlap	0.75	0.15	0.40	0.23	0.90
Overlap	Exclusives	0.56	0.67	0.49	0.34	1.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_LBD_z_3_5 Exclusive	Juan_21	0.00	0.08	-0.37	0.32	0.50
Juan_21 Exclusive	sigma_LBD_z_3_5	0.00	0.07	0.15	0.45	0.37
sigma_LBD_z_3_5 Exclusive	Juan_21 Exclusive	0.00	-0.25	-0.43	0.23	0.39
Juan_21 Exclusive	sigma_LBD_z_3_5 Exclusive	0.00	0.01	0.01	0.54	0.64
sigma_LBD_z_3_5 Exclusive	Overlap	0.00	-0.13	2.93	-0.22	-0.01
Juan_21 Exclusive	Overlap	0.00	-0.35	-0.16	-0.18	-0.10
Overlap	Exclusives	0.01	0.61	-0.04	-0.03	0.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_LBD_z_3_5 Exclusive	80	80	
Juan_21 Exclusive	20	20	
Overlap	1	1