Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
53PDD	Ismael genes	1.52e-01	1.16e-01	2.63e-01	4.87e-02
Ismael genes	53PDD	5.48e-01	6.92e-01	4.27e-03	2.63e-01



Evaluating how well 53PDD genes are linked to Ismael genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
53PDD	Ismael genes	0.60	-0.65	-1.45	-0.79	1.61
Ismael genes	53PDD	0.54	-0.06	0.81	0.33	1.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
53PDD	Ismael genes	0.00	-0.71	-1.21	-0.60	0.20
Ismael genes	53PDD	0.00	-0.81	-0.44	-0.50	-0.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
53PDD	53	53	
Ismael genes	19	19